The higher levels of testosterone in young males may somewhat play protective roles against RA Clinical improvement after a successful treatment is followed by an increase in the level of serum testosterone in RA It should be noted that patients undergoing long-term treatment with glucocorticoids may experience hypoandrogenism It means that hormonal changes may occur during the onset of RA and can affect the phenotype of the disease There are few findings regarding the importance of androgen levels in the incidence of RA, especially in males.
Lower levels of testosterone can result from primary gonadal dysfunction, and also may be due to dysfunction autoimmune rheumatoid arthritis symptoms hypothalamic-pituitary-gonadal axis, or be caused autoimmune rheumatoid arthritis symptoms an inflammation which led to lower secretion of testosterone In a study by Pikwer et al.
Therefore, it cannot be concluded that secondary inflammation ESR, CRP in early rheumatoid arthritis is the main cause of differences between the groups. Lower levels of serum testosterone may be caused by RA or may indicate the role of androgens in the pathogenesis of RA.
In a study by Dessein et al.
Another study in the USA by Masi et al. Tengstrand et al. Geenen R et al.
The prevalence of RA in males is lower than females and sexual hormones play a significant role in the pathogenesis of this disease. Males with RA may have lower levels of serum testosterone.
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Testosterone also has anti-inflammatory effects which can suppress the cellular and humoral immune systems 32 On the other hand, the male sex hormone is considered as an glükózamin kondroitin amely jobb predictive factor to treat early stages of RA; it can prove the hypothesis that the replacement of androgens can be useful in the treatment of RA However, using testosterone to treat RA is under investigation and different autoimmune rheumatoid arthritis symptoms are reported in this regard Results of the current study showed that serum testosterone levels in females with RA and DHEAs in postmenopausal females and males with RA were lower compared with the control group.
Considering that gonadal and adrenal androgens have anti-inflammatory effects which specifically reduce in inflammatory tissues, some studies showed that with lower activity of the disease resulted from treatment, the hypothalamic-pituitary-adrenal axis autoimmune rheumatoid arthritis symptoms, which led to increase in the level of serum testosterone It is noteworthy that lower levels of testosterone can cause osteoporosis; males with serum levels of testosterone lower than normal range should be treated with androgens Conclusions The current study showed that abnormal testosterone and DHEAs level in patients with RA was significantly higher than the control group.
After adjusting the effects of age and gender logistic regression analysis showed DHEAs has independent and significant association with RA. This shows the anti-inflammatory effects of gonadal and adrenal androgens in RA.
On the other hand, lower activity of the disease resulted from treatment which led to an autoimmune rheumatoid arthritis symptoms in the level of serum testosterone after improvement in hypothalamic-pituitary-adrenal axis.
Rheumatoid Arthritis (RA) Signs \u0026 Symptoms (\u0026 Associated Complications)
It may prove the hypothesis that the replacement of androgens can be useful in the treatment of RA. Acknowledgments This research was supported by a grant from the research department of Qazvin University of Medical Sciences. The authors would like to thank the participants involved in this study, the staff of the Metabolic Diseases Research Center, and the staff of the Center for Clinical Research at Qazvin Children Hospital, affiliated to Qazvin University of Medical Sciences.
Internal Medicine: Clinical Immunology - Rheumatology
Footnotes iThenticate screening: October 09,English editing: February 15,Quality control: March 02, Conflict of Interest: There is no conflict of interest to be torna térdfájdalomtól. All authors read and approved the final manuscript. References 1.
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Rheum Dis Clin North Am. Relationships between glucocorticoids and gonadal steroids in rheumatoid arthritis.